{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Podcast #296: Synthetic Cannabinoids","description":"Author: Rachael Duncan, PharmD Educational Pearls  A NEJM study report in July 2016 discussed a situation in New York during which 30 people became \u201czombie-like\u201d after ingesting synthetic cannabinoids (aka \u201cSpice). The ER managed to coordinate with the CDC to evaluate &amp;nbsp;blood samples from 18 patients who were transported to the hospital. Of those who went to the ER, the mean age was 36.8, many &amp;nbsp;of them were homeless, all of them were male. Mass spectrometry was used to confirm the presence of synthetic cannabinoid in their blood. Compared to normal THC, synthetic cannabinoids have a much lower EC50 and LD50. Spice intoxication presents in a variety of ways -patients may be hyperthermic, combative, delirious and\/or seizing. Treatment &amp;nbsp;is supportive, including fluids, cooling, electrolyte management, and sedatives.  References: Adams, A. J., Banister, S. D., Irizarry, L., Trecki, J., Schwartz, M., &amp;amp; Gerona, R. (2017). \u201cZombie\u201d Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York. New England Journal of Medicine, 376(3), 235-242. doi:10.1056\/nejmoa1610300 ","author_name":"Emergency Medical Minute","author_url":"https:\/\/www.emergencymedicalminute.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/6198023\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/fa102a\/\" height=\"90\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/18843601"}