{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"\ud83d\udee1\ufe0f Beyond Cholesterol: GIMAP6, Vascular Defense &amp; Atherosclerosis","description":"\ud83e\uddec Can atherosclerosis become lethal even without high cholesterol? A fascinating Cell study identifies GIMAP6 as an immune\u2013vascular safeguard. Loss of GIMAP6 disrupts endothelial integrity and activates a mitoROS \u2192 PPAR\u03b3 \u2192 CD36 pathway, driving macrophage lipid uptake, foam cells, inflammation, atherosclerosis, MI and heart failure\u2014even without hyperlipidemia. \u2764\ufe0f Human hypomorphic GIMAP6 variants also tracked with premature cardiovascular disease. \ud83d\udca1 Take-home: LDL matters enormously\u2014but susceptibility within the vessel wall matters too. ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/43225843\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/207313298"}