{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Hot New Drugs in Palliative Care: Max Stevenson, Alex McPherson, and Nisha Iyer","description":"When you think of palliative care pharmacotherapy, you probably think about the tried-and-true mainstays of our field like morphine, haloperidol, and senna. But the landscape of palliative symptom management is rapidly evolving, with hot new drug classes and rediscovered old-school opioids (and not just buprenorphine!) On today\u2019s episode of the GeriPal Podcast, we sit down with three expert palliative care clinical pharmacists, Max Stevenson, Alex McPherson, and Nisha Iyer, to talk about 5 hot new drugs (or rediscovered): Suzetrigine: It works for bunions (at least as well as opioids, maybe?), but can it work in palliative care?  My take-home point here is that its not ready for prime time, but you may have a different take after listening. Levorphanol: The forgotten opioid that looks a lot like methadone but more NMDA.  Should we bring it back to the living?  Maybe if it were cheaper (why does an old drug cost this much?) Tapentadol: Basically a better version of tramadol (aka Tamadont) that combines mu-opioid agonism with norepinephrine reuptake inhibition. Expensive but our guests varied in the potential benefit here. Dual Orexin Receptor Antagonists (DORAs): Rerouting sleep management away from sedating Z-drugs and benzodiazepines to these new agents seems reasonable (again if cost was no concern) given that they appear safer (check out this JAGS article on DORAs and the risk of falls) GLP-1 Receptor Agonists: Wait, GLP1\u2019s in palliative care (not just stopping it when we get consults for weight loss)? There may be a couple reasons to consider\u2026 Also check out some of these podcasts that we talked about in this episode: Gabapentinoids \u2013 Gabapentin and Pregabalin: Tasce Bongiovanni, Donovan Maust and Nisha Iyer Tramadon\u2019t: a podcast with David Juurlink about the dangers of Tramadol Buprenorphine Use in Serious Illness: A Podcast with Katie Fitzgerald Jones, Zachary Sager and Janet Ho All the Questions You Had About Opioids But Were Afraid To Ask: A Podcast with Mary Lynn McPherson   ","author_name":"GeriPal - A Geriatrics and Palliative Medicine Podcast","author_url":"http:\/\/www.geripal.org","html":"