{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"    \ud83d\udc89 Lysis Before Collapse: PRAGUE-26 Changes the PE Conversation","description":"\ud83e\udec1 Stable\u2014but not safe. Should we intervene before patients crash? PRAGUE-26 randomized 558 patients with intermediate-high\u2013risk acute pulmonary embolism to catheter-directed low-dose alteplase + anticoagulation or anticoagulation alone. The 7-day composite of death, recurrent PE, or cardiorespiratory decompensation\/collapse fell from 6.8% to 0.7% (RR 0.10; P&amp;lt;0.001)\u2014mainly through fewer episodes of decompensation. \ud83c\udfaf Major bleeding was not increased, although 2 intracranial hemorrhages occurred with thrombolysis. \ud83e\ude78 \ud83d\udca1 The emerging paradigm: prevent the crash rather than rescue it. ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/42724630\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/205833045"}