{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Cancer Prevention Clinical Trials: Reducing Risk Before Diagnosis","description":"In this episode of the Bench to Bedside podcast, Dr. Roy Jensen, vice chancellor and director of The University of Kansas Cancer Center, talks with Dr. Lauren Nye, medical oncologist and breast cancer prevention specialist, about cancer prevention clinical trials and how they differ from treatment trials by aiming to lower cancer risk or detect cancer earlier in healthy, high-risk individuals. Dr. Nye explains who may qualify based on family history, genetics, prior precancerous biopsies, or lifestyle factors, and highlights prevention successes, such as tamoxifen and the HPV vaccine. They discuss current research exploring well-tolerated, affordable options including GLP-1 receptor agonist, the heightened safety expectations for prevention studies, and why multi-agent approaches can be limited by toxicity. Dr. Nye also shares how she communicates risk\u2014especially absolute versus relative risk\u2014and encourages listeners to ask their doctor about risk assessment, genetic counseling, and high-risk clinics at KU Cancer Center. 00:00 Prevention Trials Intro 01:17 What Prevention Trials Are 02:08 Who Is High Risk 03:03 Why Prevention Matters 03:55 New Prevention Strategies 04:39 Drug Development Challenges 06:19 Patient Concerns and Safety 08:12 Why Not Combine Agents 10:10 Future of Prevention Research 11:53 Talking About Risk 13:24 Relative vs Absolute Risk 15:08 Next Steps and Wrap Up Links from this Episode: \u00b7       Learn about cancer prevention and risk reduction options at KU Cancer Center \u00b7       See open cancer prevention clinical trials at KU Cancer Center \u00b7       Learn about Dr. Lauren Nye \u00b7       Read about breast cancer genetic counseling and testing at KU Cancer Center   To ensure you get our latest updates, follow us on the social media channel of your choice by searching for KU Cancer Center. ","author_name":"Bench to Bedside","author_url":"http:\/\/benchtobedside.libsyn.com\/website","html":"