{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann","description":"Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down \u2014 and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down \u2014 and how to stop it. \ud83d\udc49 FREE Longevity Cheat Sheet \u2014 subscribe to my weekly newsletter: https:\/\/www.lisatamati.com\/lisa\/   Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down \u2014 and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol \u2014 the first comprehensive rating system for anti-aging supplements. In this episode she shares the off-label drugs, supplement stacks, and cellular strategies she uses daily to slow aging at the molecular level. We go deep on mast cell activation and its connection to aneurysms and heart attacks, why NAD infusions may be doing more harm than good, the three sirtuins you need to prioritise after 40, why she takes 70 supplements and 13 medications at low doses, and the SGLT2 inhibitor drugs that are regrowing healthy heart cells by clearing senescent zombie cells. This is one of the most important longevity conversations I have had on the show. \u23f1\ufe0f TIMESTAMPS: 0:00 - Teaser: Senolytic drugs that regrow healthy heart cells 0:20 - Welcome and intro to Dr Sandra Kaufmann 1:38 - Sandra's background: cell biologist to longevity expert 3:14 - The Post-it note office and chasing the aging puzzle 8:33 - The Seven Tenets of Aging overview 10:19 - Tenet 3: Sirtuins, AMPK, mTOR, and circadian rhythms 11:54 - Tenet 4: DNA repair, proteostasis, autophagy 13:07 - Deep dive: Mast cells and tissue destruction 14:16 - Mast cells, heart attacks, and aneurysms 17:43 - Mastering the Mast Cell: Sandra's new publication 21:06 - Stress triggers mast cell degranulation 23:04 - Mast cell stabilisers: supplements and drugs 27:17 - Sirtuins 1, 3, and 6: the keys to cellular homeostasis 30:05 - Best activators: pterostilbene, DHM, fucoidan 33:38 - The NAD debate: NMN vs NR vs infusions 36:23 - Why NAD IV infusions are a bad idea 39:06 - Rotating NAD precursors: Sandra's approach 44:52 - NRF2 pathway and why daily glutathione is a mistake 50:05 - 70 supplements and 13 drugs at low synergistic doses 56:50 - Rapamycin: Sandra says no 57:51 - Metformin: 250-500mg not 2000mg 1:00:16 - The Flozins: glucose excretion plus senolytic activity 1:02:32 - Epalrestat: blocking the glucose to fructose conversion 1:04:41 - Sandra's 5 daily eye drops protocol 1:08:13 - Naringenin, nobiletin, and the orange peel stack 1:11:28 - Supplement roundup and the Kaufmann Rating System 1:15:23 - Where to find Dr Sandra Kaufmann   SPONSOR MESSAGE This episode is brought to you by MitoSynergy. If you are looking for next-level mitochondrial support, MitoSynergy delivers bioavailable copper in a patented form that supports energy production at the cellular level. Head to mitosynergy.com\/lisaTamati and you will get 10% off your order. And if you have not tried Re:juvenate Pro yet, this is the supplement I formulated with my biotech company Aevum Labs. It is not another NAD supplement. Re:juvenate Pro targets immunosenescence, the aging of your immune system, which sits upstream of so many of the problems Sandra and I discussed today. It contains kawakawa, carnosic acid, Immunel colostrum extract, and Immune Defense Protein working across multiple pathways including NRF2 activation, gut barrier support, and immune modulation. It is the first thing I put in every client protocol and it is what I give my mum every single day. You can grab it at    https:\/\/shop.lisatamati.com\/pages\/rejuvenate   \ud83d\udd17 LINKS MENTIONED IN THIS EPISODE: Website: kaufmannprotocol. Website: kaufmannprotocol.com Clinical practice: kaufmannlongevity.com Instagram: instagram.com\/kaufmannantiaging Books: amazon.com\/stores\/Dr-Sandra-Charlotte-Kaufmann\/author\/B07BDL1WV8 E-treatise: Mastering the Mast Cell (search Amazon) Club Exosome: quarterly in Las Vegas with Steve McCain  \u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501 \ud83c\udf10 Website: https:\/\/www.lisatamati.com \ud83d\uded2 Supplements: https:\/\/shop.lisatamati.com \ud83c\udf99\ufe0f Podcast: https:\/\/www.lisatamati.com\/podcast \ud83d\udce7 Contact: support@lisatamati.com \u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501 About Lisa Tamati: Longevity specialist, functional health practitioner, co-founder of Aevum Labs (home of Rejuvenate Pro), and host of Pushing The Limits \u2014 a globally top-200-ranked health podcast. Author of 4 books. ","author_name":"Pushing The Limits","author_url":"https:\/\/www.lisatamati.com","html":"