{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"A Blood Test Before Symptoms: PPP2R5C and the Molecular Clock of Alzheimer\u2019s","description":"\ud83e\udde0 Alzheimer\u2019s doesn\u2019t begin when memory fails \u2014 it begins years earlier. &amp;nbsp; A new Cell Reports Medicine study identifies PPP2R5C, a brain-derived protein detectable in blood, that declines before significant Tau hyperphosphorylation. &amp;nbsp; \ud83d\udcc9 \u2193 61% in amnestic mild cognitive impairment \ud83d\udcca AUC 0.85 for Alzheimer\u2019s diagnosis \ud83d\udd2c Mechanism: activates Protein Phosphatase 2A and ULK1-driven autophagy to regulate Tau &amp;nbsp; A blood signal before symptoms. Early detection means earlier intervention. ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/40186345\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/198821370"}