{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Joel Hirschhorn: How Genes Add Up","description":"Howie and Harlan are joined by geneticist and endocrinologist Joel Hirschhorn to discuss how thousands of genetic variants collectively shape disease and traits like height and obesity. Harlan reviews new research on diet soda and dementia; Howie surveys recent market swings, including the rise of Solace Health and the decline of Hims & Hers. Show notes: Diet Soda and Dementia \u201cSoda consumption and risk of dementia: The Northern Manhattan study\u201d  \u201cWhy One Cardiologist Has Drunk His Last Diet Soda\u201d Joel Hirschhorn National Human Genome Research Institute: Mendelian Inheritance MedlinePlus: FGFR3 gene  Cleveland Clinic: Achondroplasia National Human Genome Research: Polygenic Trait  Hirschhorn Lab \u201cA saturated map of common genetic variants associated with human height\u201d  \u201cWhat are single nucleotide polymorphisms (SNPs)?\u201d ScienceDirect: Genetic Variant Joel Hirschhorn: \u201cGenome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci\u201d Joel Hirschhorn: \u201cPolygenic prediction of body mass index and obesity through the life course and across ancestries\u201d \u201cObesity Prediction Could Be Guided by Genetic Risk Scores\u201d \u201cGenome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of \u03b2-thalassemia\u201d  Society for Science: Noam Elkies MIT: Eric S. Lander Ups and Downs \u201cUnderstanding Creative Destruction: Driving Innovation and Economic Change\u201d \u201cSolace Health raises $130M series C for advocacy platform\u201d \u201cMolina Healthcare's stocks fall as company plans exit from Medicare Advantage\u201d  \u201cCentene swings to loss but predicts stabilization in 2026\u201d \u201cUnitedHealth limps into 2026 with a smaller business and fresh challenges\u201d \u201cHims & Hers Falls 14% After Pulling Copycat Wegovy Pill\u2014Novo Nordisk Up 8%\u201d  \u201cCompounding and the FDA: Questions and Answers\u201d In the Yale School of Management\u2019s MBA for Executives program, you\u2019ll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions. ","author_name":"Health & Veritas","author_url":"https:\/\/insights.som.yale.edu\/podcasts\/health-veritas","html":"