{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"254 The Gut Microbiome-Inflammation Connection and Accelerated Aging with Martha Carlin","description":"What if stubborn weight gain, brain fog, poor sleep, and chronic inflammation aren\u2019t \u201cjust aging\u201d\u2014but signals from your gut that started decades earlier? Today\u2019s conversation challenges the myth of inevitable decline and shows how understanding your microbiome can make your chronological age truly just a number. After 40, many people find that diets stop working, digestion becomes unpredictable, hormones feel out of control, and inflammation quietly creeps in. This episode explains why gut healing becomes harder with age, what\u2019s actually changing biologically, and how restoring gut resilience can transform metabolism, hormones, and healthy longevity. Today\u2019s guest brings a rare blend of microbiome research, systems thinking, and real-world clinical insight to guide us. Martha Carlin is a pioneering citizen scientist and microbiome systems researcher. She is the founder and CEO of The BioCollective, collaborating with institutions including Caltech, the University of Chicago, and University College Cork. Her work focuses on how gut microbes drive inflammation, insulin resistance, and chronic disease as we age. Martha\u2019s mission began personally\u2014after her husband\u2019s Parkinson\u2019s diagnosis\u2014leading her to leave a corporate career to investigate healing at the root: the gut.  Episode Timeline: 00:00 \u2014 Aging symptoms, gut health, and the microbiome 03:30 \u2014 Why gut issues worsen after 40 and why aging conversations miss the microbiome 05:10 \u2014 Martha\u2019s personal journey into microbiome science after Parkinson\u2019s diagnosis 08:45 \u2014 Antibiotics, missing microbes, and early Parkinson\u2019s gut research 12:30 \u2014 What biologically changes in the gut with age 15:40 \u2014 Endotoxins, gram-negative bacteria, and chronic inflammation 18:20 \u2014 Constipation as an early warning sign, not a nuisance 21:00 \u2014 Surfactants, cleaners, bile acids, and hormone recirculation 23:40 \u2014 Soil microbiomes and what agriculture teaches us about gut healing 26:30 \u2014 Food quality, seed oils, and modern processing challenges 28:40 \u2014 Beet kvass and fermented foods for nitric oxide and gut support 30:20 \u2014 The estrobolome, cortisol, insulin, and hormone\u2013gut feedback loops 33:00 \u2014 Practical first steps to restore gut resilience 36:30 \u2014 Common mistakes: extreme diets, fasting, and overcorrection 39:10 \u2014 Women, cortisol, and metabolic backlash 41:40 \u2014 Listener guidance: simple daily changes that matter most 43:30 \u2014 Guest resources Call to Action:  Connect with Martha Carlin:  https:\/\/www.instagram.com\/biotiquest https:\/\/www.facebook.com\/BiotiQuest https:\/\/www.youtube.com\/@BiotiQuest https:\/\/twitter.com\/biotiquest https:\/\/www.linkedin.com\/company\/biotiquest  Connect with Dr. Gillian Lockitch Download your guide to Build Back a Better Body: Strengthen Bones, Muscles, Joint and Fascia  Connect with Dr. Gillian Lockitch at askdrgill@gmail.com to request a phone conversation or zoom call   Join the Growing Older Living Younger Facebook Community here  Share the Growing Older Living Younger podcast link for anyone you care about and invite them to subscribe     ","author_name":"Growing Older Living Younger: About longevity, wellness, healthspan,","author_url":"https:\/\/askdrgill.com","html":"