{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"218: Metagenomics in Clinical Microbiology","description":"In this episode of Let\u2019s Talk Micro, we break down metagenomic next-generation sequencing (mNGS) and how it\u2019s changing the way we diagnose complex infectious diseases. I\u2019m joined by Steve Miller, MD, PhD\u2014Chief Medical Officer at Delve Bio\u2014to discuss how unbiased metagenomics moved from research labs into real-world clinical practice. We cover what metagenomics is, how it differs from targeted PCR and sequencing, and where it adds the most value\u2014especially in meningitis and encephalitis, immunocompromised patients, and cases where routine testing comes back negative. Dr. Miller shares insights from years of clinical experience, including how mNGS can improve diagnostic yield, shorten time to diagnosis, guide targeted therapy, and reduce unnecessary testing and hospital stays. We also touch on challenges like cost, result interpretation, diagnostic stewardship, and where metagenomics is headed next\u2014including its role in public health and emerging infections.    Links & Resources Clinical metagenomics for meningitis and encephalitis (Nature Medicine) https:\/\/www.nature.com\/articles\/s41591-024-03275-1    Stay connected with Let\u2019s Talk Micro: Website: letstalkmicro.com Questions or feedback? Email me at letstalkmicro@outlook.com Interested in being a guest on Let\u2019s Talk Micro? Fill out the form here: https:\/\/forms.gle\/V2fT3asjfyusmqyi8 Support the podcast: Venmo Buy me a Ko-fi   ","author_name":"Let's Talk Micro","author_url":"https:\/\/asm.org\/LetsTalkMicro","html":"