{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"A Molecular Autopsy in Real Time \ud83e\uddec\u23f1\ufe0fCheckpoint Inhibitors, Multiorgan Damage \u265f\ufe0f\ud83e\uddec\u26a0\ufe0f","description":"\ud83e\uddec When immunity saves\u2014and harms\u2014at the same time &amp;nbsp; A striking NEJM correspondence reveals that patients receiving immune checkpoint inhibitors often sustain molecularly detectable multiorgan damage\u2014weeks to months before symptoms appear. Using cell-free DNA methylation mapping, investigators show that immune-related adverse events are systemic, not isolated organ toxicities\u2014the visible clinic finding is just the tip of the iceberg \ud83e\uddca\ud83e\uddec &amp;nbsp; This work reframes irAEs as a global loss of immune tolerance and opens the door to early, molecular surveillance\u2014particularly relevant for cardio-oncology and precision medicine. &amp;nbsp; \ud83d\udccd Source: The New England Journal of Medicine, December 2025 #Immunotherapy #CardioOncology #PrecisionMedicine #cfDNA #NEJM #TranslationalScience ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/39446595\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/196664765"}