{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"The Unnecessarily Complex Story of Rheumatoid Factor","description":"The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery\u2026that happened twice.&amp;nbsp;  Intro&amp;nbsp;0:15 Rheumatoid factor quick background and history&amp;nbsp;00:36 Rheumatology blood tests&amp;nbsp;3:02 What is Rheumatoid factor?&amp;nbsp;3:49 Spiderman and latex agglutination: Testing for rheumatoid factor&amp;nbsp;4:50 The double discovery of rheumatoid factor&amp;nbsp;8:03 Putting agglutination on the medical map in 1896&amp;nbsp;10:08 Pop Quiz!&amp;nbsp;11:21 Serotherapy&amp;nbsp;13:10 When did we start using agglutination for testing?&amp;nbsp;14:17 First discovery of blood groups&amp;nbsp;14:50 The complement fixation test&amp;nbsp;17:22 Testing for syphilis with complement fixation and agglutination&amp;nbsp;21:01 The first discovery of rheumatoid factor&amp;nbsp;24:11 We forget about rheumatoid factor&amp;nbsp;27:44 Rediscovering rheumatoid factor&amp;nbsp;28:20 Analytical ultracentrifugation&amp;nbsp;32:50 What rheumatoid factor is used for&amp;nbsp;36:01 Thanks for listening&amp;nbsp;38:22  We\u2019d love to hear from you! Send your comments\/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Assadian O et al. Wien Klin Wochenschr. 2010;doi:10.1007\/s00508-009-1297-1  Edelman GM, et al. J Exp Med. 1958;doi:10.1084\/jem.108.1.105  Franklin EC, et al. J Exp Med. 1957;doi:10.1084\/jem.105.5.425  Fraser KJ. Semin Arthritis Rheum. 1988;doi:10.1016\/0049-0172(88)90035-2 Jonsson R. Ann Rheum Dis. 2020;doi:10.1136\/annrheumdis-2019-216822  Mohd Noor NH, et al. Cureus. 2024;doi:10.7759\/cureus.68903  Tan EM, et al. J Exp Med. 2016;doi:10.1084\/jem.20160792 Disclosures: Brown reports no relevant financial disclosures. ","author_name":"Healio Rheuminations","author_url":"http:\/\/rheuminations.healio.libsynpro.com\/website","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/38564140\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/87A93A\/\" height=\"90\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/194154365"}