{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"Mitochondria, Mistakes, \ud83e\uddec InflammAgeing","description":"\ud83d\udd2c Exciting new insights from Nature (2025)! When mitochondria run low on the right building blocks (deoxyribonucleotides), they mistakenly weave ribonucleotides into their DNA \ud83e\uddec. The result? Fragile mitochondrial DNA gets expelled, setting off the cGAS\u2013STING pathway and fueling inflammation \ud83d\udd25\u2014a key feature of ageing and senescence. &amp;nbsp; \ud83e\uddea In MGME1-deficient mice, this process drives renal inflammation, while supplementation with deoxyribonucleosides \ud83d\udc8a can calm the storm. &amp;nbsp; \u2728 A major step in understanding \u201cinflammageing\u201d and potential interventions for age-related diseases. &amp;nbsp; #Mitochondria #DNA #Ageing #Inflammation #NaturePaper ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/38408390\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/193617855"}