{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"Does PACAP 38 Work Differently Than CGRP?","description":"New research shows CGRP monoclonal antibody treatment may not prevent migraine attacks triggered by the neuropeptide PACAP-38. This study suggests PACAP-38 may act through a different pathway and could become a future preventive option for people who don\u2019t respond to CGRP-based treatments. Molly O\u2019Brien explains in this Migraine Minute News Update.&amp;nbsp; Read More: https:\/\/bit.ly\/4ivy3LG Images courtesy: Springer Nature. The Journal of Headache and Pain. doi: 10.1186\/s10194-025-02022-2 Creative Commons license: https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/   Script: Does PACAP 38 Work Differently Than CGRP? A new study published in the Journal of Headache and Pain found that migraine attacks can be triggered by the neuropeptide PACAP-38 despite pre-treatment with a CGRP monoclonal antibody. Researchers gave 38 participants with migraine an infusion of eptinezumab\u2014a CGRP monoclonal antibody\u2014or placebo, followed by PACAP-38. The results showed no difference in the incidence of migraine attacks between the two groups. This study suggests that PACAP-38 may trigger migraine attacks through a different pathway than CGRP. Treatments targeting PACAP-38 may offer a new preventive option for people who\u2019ve had limited or no success with CGRP monoclonal antibodies.   ","author_name":"Migraine Minute News Update","author_url":"http:\/\/migraineminute.libsyn.com\/","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/36554920\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/256d9f\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/item\/36554920"}