{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":300,"width":600,"title":"Genes, Gender, and Growing Old","description":"\ud83e\uddec Your mother\u2019s X chromosome may shape how your brain ages. In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory \ud83e\udde0\ud83d\udd73\ufe0f than those with random X-inactivation. This is due to imprinted genes \u2014 some only expressed from the paternal X (Xp) \u2014 which are silent when Xm dominates. &amp;nbsp; \ud83e\udde0\ud83d\udca1 Using CRISPR\u2013Cas9, researchers reactivated 3 Xm-silent genes (Sash3, Tlr7, Cysltr1) and saw improved memory and mitochondrial function \u26a1\ud83d\udd0b. &amp;nbsp; \ud83d\udc69\u200d\ud83d\udd2c This highlights inter-female variation in aging and memory \u2014 and suggests that epigenetic inheritance from mothers may shape how well we remember\u2026 or forget. \ud83e\uddd3\ud83e\udde0\u2753 ","author_name":"Dr. RR Baliga's 'Podkast for the Kurious Doc'","author_url":"http:\/\/www.MasterMedFacts.com","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/35819990\/height\/300\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/88AA3C\/\" height=\"300\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/186102565"}