{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology","description":"This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Intro 0:11  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; In this episode 0:22  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Review of episode 83 1:23  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Listen to previous episode,  The Complement System for Dunces 4:09  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Anti-C1q antibodies 6:26  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Lupus, anti-C1q and lupus nephritis 9:33  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; What happens when you inject anti-C1q in a mouse? 12:56  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; The allergy component: anti-C1q, urticaria and angioedema 17:36  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Bradykinin-mediated angioedema and C1q deficiency 24:20  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; What is the kinin kallikrein system? 26:21  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; French researchers in 1909: human urine injected in dogs 27:30  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; How is this relevant to urticarial vasculitis? 31:08  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; SERPING1 gene mutation 31:23  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Summary 32:06  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; COPD association with urticarial vasculitis 33:51  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Coming up in episode 85 35:28  \u00b7&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Thanks for listening 35:45 Disclosures: Brown reports no relevant financial disclosures. We\u2019d love to hear from you! Send your comments\/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References:  Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016\/j.jaip.2021.11.011.  Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016\/j.jaip.2018.05.006.  Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016\/j.anai.2023.06.014.  Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016\/j.jaci.2022.02.007.  Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006\/clin.1993.1066. Stojan G, et al. Lupus. 2016;doi:10.1177\/0961203316645205. Venzor J, et al. Clin Rev Allergy Immunol. 2002;doi:10.1385\/CRIAI:23:2:201.  Wisnieski JJ, et al. Medicine. 1995;doi:10.1097\/00005792-199501000-00003. ","author_name":"Healio Rheuminations","author_url":"http:\/\/rheuminations.healio.libsynpro.com\/website","html":"<iframe title=\"Libsyn Player\" style=\"border: none\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/30882783\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/forward\/render-playlist\/no\/custom-color\/87A93A\/\" height=\"90\" width=\"600\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen><\/iframe>","thumbnail_url":"https:\/\/assets.libsyn.com\/secure\/content\/170890953"}