{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"Ep. 16: Understanding HNE, Biomarkers, and LPO\u2014with Matt Quinn and Dr. Brian Kerley","description":"Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. \u201cThe study of lipid peroxidation (LPO) processes has become a rapidly growing \ufb01eld in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1)    Asthma (2)    Atherosclerosis (3)    Alzheimer\u2019s disease (4)    Rheumatoid arthritis (5)    Burn injury (6)    Cataractogenesis (7)    Diabetes (8)    Endotoxin liver injury (9)    Multiple sclerosis (10)Myocardial infarction (11)Organ transplantation (12)Parkinson disease (13)Psoriasis (14)Reperfusion injury (15)Stroke (16)Aging \u201cThe obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation. \u201cThese efforts are expressed in the exploding \ufb02ood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identi\ufb01cation techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.\u201d (Spiteller 1998) Guest info Matt Quinn https:\/\/twitter.com\/Mqsley https:\/\/www.mquinn.online\/   Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here\u200b I'm in the very early stages of building\/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet\/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https:\/\/www.mquinn.online\/ _______________________________________ Co-host Dr. Brian Kerley https:\/\/www.seedoilrebellion.com\/ https:\/\/twitter.com\/SeedOilDsrspctr   Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https:\/\/www.seedyapp.com\/   Tucker Goodrich Substack: https:\/\/tuckergoodrich.substack.com\/ Twitter: https:\/\/twitter.com\/TuckerGoodrich Youtube: https:\/\/www.youtube.com\/tuckergoodrich0 Apple podcast: https:\/\/podcasts.apple.com\/us\/podcast\/tucker-goodrich-podcast\/id1617481825 Spotify podcast: https:\/\/open.spotify.com\/show\/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https:\/\/sites.libsyn.com\/408758 Blog (deprecated, but still a lot there!): http:\/\/yelling-stop.blogspot.com\/ _______________________________________ Show Notes Episode 14 Post Script: Matt Has a Surprising Easter Egg https:\/\/youtu.be\/1D17vUvbHhk   Spiteller, G. (1998). Linoleic Acid Peroxidation\u2014The Dominant Lipid Peroxidation Process in Low Density Lipoprotein\u2014And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105\u2013162. https:\/\/doi.org\/10.1016\/S0009-3084(98)00091-7   If you have any questions about sources for things discussed please ask in the comments. ","author_name":"Tucker Goodrich: Debugging Life","author_url":"https:\/\/sites.libsyn.com\/408758","html":"