{"version":1,"type":"rich","provider_name":"Libsyn","provider_url":"https:\/\/www.libsyn.com","height":90,"width":600,"title":"467: Prion Pivots Productive Pathways","description":"This episode: Prions in yeast can allow better adaptation to changing conditions! Download Episode (9.5 MB, 13.9 minutes) Show notes: Microbe of the episode: Hepatovirus F   News item   Takeaways Prions can be deadly. They're misshapen proteins that cause a cascade of misfolding of similar proteins if they get into the nervous system, resulting in neurodegeneration in mammals. But in other organisms, they are not always so scary; some fungi use prions to regulate their behavior in varying conditions.   In this study, a prion allows yeast to switch between a fast-growing lifestyle with shorter reproductive lifespan that can be beneficial in conditions where nutrients are often plentiful, and a slower-growing but more enduring lifestyle that helps in more scarce conditions.   Journal Paper: Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. 2021. A prion accelerates proliferation at the expense of lifespan. eLife 10:e60917. Other interesting stories: Modified yeast probiotic could tune its effects as needed by sensing bowel inflammation   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook. ","author_name":"BacterioFiles","author_url":"https:\/\/www.asm.org\/bacteriofiles","html":"