1 rich Libsyn https://www.libsyn.com 300 600 🫀 Could the aging heart have a drainage problem? A fascinating study in Nature Cardiovascular Research shows that aging reduces cardiac lymphatic vessels, with tighter junctions, impaired clearance, inflammation, edema, fibrinogen and amyloid accumulation. 🔥 🧬 Mechanistically: aging → ↓VEGFC → ↑nuclear IL-33 → lymphatic endothelial cell loss/remodeling. 🎯 IL-33 silencing or VEGFC restoration rescued lymphatic density and reduced inflammation—but VEGFC did not reverse established diastolic dysfunction. 💡 Perhaps cardiac aging is not only about blood vessels. Lymphatics matter Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity! http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/42923287/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/206337247