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  <title>Episode 498: Do You Want a One and Done Cholesterol Infusion? The Long Road Ahead</title>
  <description>Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead.  Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 &amp;quot;normal&amp;quot; range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab.  Sponsored by Igennus — visit igennus.com/drkahn for 20% off. </description>
  <author_name>Heart Doc VIP with Dr. Joel Kahn</author_name>
  <author_url>https://www.kahnlongevitycenter.com/</author_url>
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