1 rich Libsyn https://www.libsyn.com 300 600 🧬 Predict. Prevent. Protect: The APOL1 Proteomic Revolution A fascinating new study in Nature Medicine describes a 9-protein APOL1 Proteomic Risk Score (APRS) capable of predicting kidney disease progression years before chronic kidney disease becomes clinically apparent. Among individuals of African ancestry with APOL1 high-risk genotypes and preserved kidney function, APRS achieved a remarkable time-dependent AUC of ~86%, substantially outperforming traditional clinical scores and polygenic risk tools. This work moves us closer to precision nephrology: identifying who is truly at risk, enriching clinical trials, and potentially guiding targeted therapies such as inaxaplin. A powerful example of proteomics transforming static genetic risk into dynamic clinical prediction. 🔬🩺 Li C et al. Nature Medicine. 2026. doi:10.1038/s41591-026-04337 Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity! http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/41242675/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/201806300