1 rich Libsyn https://www.libsyn.com 300 600 🧠 Three major stroke trials published in JAMA this week may reshape adjunctive reperfusion strategies in acute ischemic stroke. &amp;nbsp; 🔹 TNK-PLUS: Tenecteplase before thrombectomy in late-window stroke showed no added functional benefit. 🔹 CHOICE-2: Intra-arterial alteplase after successful thrombectomy improved excellent neurological recovery, though mortality signals warrant caution. 🔹 INSTANT: Early tirofiban after inadequate tenecteplase response significantly improved 90-day outcomes in non-large vessel occlusion stroke. &amp;nbsp; Together, these studies highlight a growing shift from merely reopening arteries toward optimizing microvascular reperfusion and tissue recovery. Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity! http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/41232195/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/201771975