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  <title>How Bitter Taste Receptors in Your Gut Can Instantly Kill Food Cravings - Episode 339</title>
  <description>In this episode, Dr. Gladden and nutrition expert Sarah Kennedy discuss Calocurb, a natural extract that uses evolutionary biology to suppress appetite. The discovery focuses on bitter taste receptors (T2Rs) located throughout the gastrointestinal tract, which historically served as a protective mechanism to slow the consumption of potentially toxic substances. By using a specific New Zealand hop extract, Calocurb triggers these receptors to signal the brain that the body is full. This process stimulates the natural release of satiety hormones—GLP-1, CCK, and PYY—effectively quieting &amp;quot;hunger noise&amp;quot; and reducing caloric intake without the need for synthetic pharmaceuticals. &amp;amp;nbsp; For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe   If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now &amp;amp;nbsp;  Use code 'Podcast10' to get 10% OFF on any of our supplements at&amp;amp;nbsp;https://gladdenlongevityshop.com/!&amp;amp;nbsp; &amp;amp;nbsp; Takeaways  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Sarah Kennedy transitioned from veterinary medicine to nutrition.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Calocurb is based on the hypothesis of appetite suppression through bitter taste receptors.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Bitter taste receptors are present throughout the gastrointestinal tract.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; The primary hormones involved in appetite suppression are CCK, GLP-1, and PYY.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Clinical studies showed an 18% reduction in calorie intake with Calocurb.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Calocurb has a duration of action of four to six hours.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; 5% of users may experience a laxative effect as a side effect.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; The product can be used intermittently for weight management.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Future research will explore the effects of Calocurb on adolescents and gut health.  ·&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp;&amp;amp;nbsp; Calocurb is a natural alternative to synthetic appetite suppressants. &amp;amp;nbsp; Chapters 00:00 Introduction to Calocurb and Sarah's Background 02:52 The Science Behind Appetite Suppression 05:56 Mechanisms of Action: Hormones and Receptors 08:55 Clinical Studies and Results of Calocurb 11:50 Long-term Effects and Usage Recommendations 14:57 Side Effects and Adaptation 17:57 Future Research and Development Plans 21:01 Conclusion and Where to Find Calocurb    To learn more about Sarah Kennedy: Facebook: https://www.facebook.com/calocurbGLOBAL/  Instagram: https://www.instagram.com/calocurb  Website: www.calocurb.com &amp;amp;nbsp; Reach out to us at: &amp;amp;nbsp;&amp;amp;nbsp;  Website: https://gladdenlongevity.com/  &amp;amp;nbsp;&amp;amp;nbsp;  Facebook: https://www.facebook.com/Gladdenlongevity/ &amp;amp;nbsp;&amp;amp;nbsp;  Instagram: https://www.instagram.com/gladdenlongevity/?hl=en  &amp;amp;nbsp;&amp;amp;nbsp;  LinkedIn: https://www.linkedin.com/company/gladdenlongevity &amp;amp;nbsp;&amp;amp;nbsp;  YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw    &amp;amp;nbsp; &amp;amp;nbsp; Gladden Longevity Podcast Disclosures  Production &amp;amp;amp; Independence  The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden’s clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.  Medical Disclaimer  The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener’s own risk.  Podcast Guest Disclosures  Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.  Sponsorships &amp;amp;amp; Affiliate Disclosures  To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.  Additional Note on Content Integrity  All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications. </description>
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