1 rich Libsyn https://www.libsyn.com 300 600 A large nationwide cohort study in JAMA compared amoxicillin-clavulanate vs amoxicillin for acute sinusitis in &amp;gt;500,000 adults. Treatment failure was low (~3%) with no significant difference between groups (RR 0.96). However, broader-spectrum therapy increased secondary infections, including yeast and C. difficile. &amp;nbsp; The message is clear: narrow-spectrum amoxicillin remains a rational first-line choice for uncomplicated sinusitis—balancing efficacy, safety, and stewardship. &amp;nbsp; Sometimes, the quiet drug wins the loud debate. Dr. RR Baliga's 'Podkast for the Kurious Doc' http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/40949905/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/201010415