1 rich Libsyn https://www.libsyn.com 300 600 🫀🧠🛡️ Sense. Signal. Scar. &amp;nbsp; A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm). &amp;nbsp; Intervening at any node improved ejection fraction, reduced infarct size, and normalized autonomic balance—pointing to neuroimmune modulation as a new therapeutic frontier beyond myocardium-centric care. &amp;nbsp; 📌 Key takeaway: Treat the circuit, not just the scar. 📖 Yadav et al., Cell (2026)&amp;nbsp; Dr. RR Baliga's 'Podkast for the Kurious Doc' http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/39958205/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/198121885