1 rich Libsyn https://www.libsyn.com 300 600 🧬 When immunity saves—and harms—at the same time &amp;nbsp; A striking NEJM correspondence reveals that patients receiving immune checkpoint inhibitors often sustain molecularly detectable multiorgan damage—weeks to months before symptoms appear. Using cell-free DNA methylation mapping, investigators show that immune-related adverse events are systemic, not isolated organ toxicities—the visible clinic finding is just the tip of the iceberg 🧊🧬 &amp;nbsp; This work reframes irAEs as a global loss of immune tolerance and opens the door to early, molecular surveillance—particularly relevant for cardio-oncology and precision medicine. &amp;nbsp; 📍 Source: The New England Journal of Medicine, December 2025 #Immunotherapy #CardioOncology #PrecisionMedicine #cfDNA #NEJM #TranslationalScience Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity! http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/39446595/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/196664765