1 rich Libsyn https://www.libsyn.com 300 600 The immune clock starts earlier than we think ⏳🧬 &amp;nbsp; A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty. &amp;nbsp; Using &amp;gt;16M single-cell profiles and longitudinal vaccine responses, researchers found: • Stable, early transcriptional drift in naïve &amp;amp; memory T cells • A subtle TH2 shift that may weaken antiviral antibody quality • Reduced IgG class-switching to repeat flu antigens (e.g., B/Phuket) • No acceleration from CMV infection despite compositional shifts &amp;nbsp; The message? Immune aging is gradual, not abrupt — and midlife may be the window for intervention. &amp;nbsp; Precision immunology will increasingly mean precision geroscience. Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity! http://www.MasterMedFacts.com <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/38902250/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/195084850