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  <title>Beyond LDL-Cholesterol: These Culprits Drive Artery Plaque Build Up</title>
  <description>For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels… Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque build-up, even if your LDL-Cholesterol levels are low. Sponsored: Crush your Workouts and stay hydrated this summer with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix *Save with code podcast at checkout Link to Video and Show Notes: https://bit.ly/3WfpI5R Research Mentioned: Zanoni, P., Velagapudi, S., Yalcinkaya, M., Rohrer, L. &amp;amp;amp; Eckardstein, A. von. Endocytosis of lipoproteins. Atherosclerosis 275, 273–295 (2018).  Ference, B. A., Braunwald, E. &amp;amp;amp; Catapano, A. L. The LDL cumulative exposure hypothesis: evidence and practical applications. Nat. Rev. Cardiol. 1–16 (2024) doi:10.1038/s41569-024-01039-5. Time Stamps: 00:45 LDL's link with atherosclerosis is nuanced.  &amp;amp;nbsp;02:30 Initial damage to the arterial wall makes LDL levels problematic.  03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils.  08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk.  09:50 Start with diet and exercise together.  11:20 Statins have concerning side effects.  13:15 Plaque formation begins early in life.  13:50 High LDL is found in centenarians.  14:44 Centenarians are metabolically healthy.  15:40 Your liver makes LDL cholesterol.  16:10 Every cell in your body requires cholesterol.  18:00 &amp;amp;nbsp;Diets high in seed oils make your LDL more likely to be oxidized.  20:55 30-50% of people who have heart attacks have optimal serum cholesterol. </description>
  <author_name>High Intensity Health with Mike Mutzel, MS</author_name>
  <author_url>http://highintensityhealth.com</author_url>
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