1 rich Libsyn https://www.libsyn.com 300 600 BBSome trains provide receptors a passage out of cilia Many G protein–coupled receptors accumulate in the membrane of primary cilia and then exit this sensory organelle when their signaling pathway is activated.&amp;nbsp;Ye et al.&amp;nbsp;reveal that the BBSome complex facilitates the signal-dependent exit of GPCRs by moving them across a diffusion barrier located at the ciliary transition zone, although the receptors must then cross a second, periciliary diffusion barrier to completely exit the cilium. This biosights episode presents the paper by Ye et al. from the May 7th, 2018, issue of the&amp;nbsp;Journal of Cell Biology&amp;nbsp;and includes an interview with the paper's senior author, Maxence Nachury (University of California, San Francisco). Produced by Caitlin Sedwick and Ben Short. See the associated paper in&amp;nbsp;JCB&amp;nbsp;for details on the funding provided to support this original research. Subscribe to biosights via&amp;nbsp;iTunes&amp;nbsp;or&amp;nbsp;RSS View&amp;nbsp;biosights archive The Rockefeller University Press biosights@rockefeller.edu biosights http://www.jcb.org/biosights <iframe title="Libsyn Player" style="border: none" src="//html5-player.libsyn.com/embed/episode/id/6564097/height/300/theme/custom/thumbnail/yes/direction/forward/render-playlist/no/custom-color/88AA3C/" height="300" width="600" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> https://assets.libsyn.com/secure/content/53675783